I was just reading a post from the Los Angles Times that was talking about another Propecia side effect. For those that don’t know Propecia is a prescription drug used to fight male-pattern baldness and it’s know to cause long-lasting sexual dysfunction and depression. (National Library of Medicine / National Institutes of Health / August 8, 2012)
According to a study published in the Journal of Clinical Psychiatry the hair loss drug Propecia (1 mg finasteride) has been linked to severe depression, even long after use of the drug is stopped.
Endocrinologist Michael S. Irwig, MD, of the George Washington University Hospital, studied more than sixty former users of this drug including a number who had suffered sexual side effects for at least three months and compared them with a group of healthy balding men who had never used Propecia and had no psychiatric symptoms.
Dr. Irwig found that moderate or severe depressive symptoms were present in sixty four percent of the former Propecia users, but in zero percent of the control group.
In explaining the phenomenon reported in the recent study the investigators suggested that Finasteride can cross the blood-brain barrier. In the brain, it blocks the action of an enzyme that alters the levels of hormone-derived neuroactive steroids, including a metabolite that can bind to receptors for the gamma-aminobutyric acid (GABA) neurotransmitter system, which has been implicated in anxiety and depression.
Drawing conclusions from the research, Dr. Irwig advised that “men who report persistent sexual difficulties after taking finasteride should consider being screened for depression, and additional controlled studies should be undertaken.”
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